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JoVE Journal
Developmental Biology

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Epigenetic Conversion as a Safe and Simple Method to Obtain Insulin-secreting Cells from Adult Skin Fibroblasts
 

Epigenetic Conversion as a Safe and Simple Method to Obtain Insulin-secreting Cells from Adult Skin Fibroblasts

Article DOI: 10.3791/53880 08:45 min March 18th, 2016
March 18th, 2016

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Summary

Here, a new method that allows the conversion of adult skin fibroblasts into insulin-secreting cells is presented. This technique is based on epigenetic conversion, does not involve the use of retroviral vectors nor the acquisition of a stable pluripotent state. It is therefore highly promising for translational medicine applications.

Transcript

Tags

Epigenetic Conversion Insulin-secreting Cells Adult Skin Fibroblasts Regenerative Medicine Cell Therapy Diabetes Phenotype Switch Pluripotency Retroviral Vectors Georgia Pennarossa Sterile Gelatin Petri Dishes Human Skin Biopsies Fibroblast Medium Cell Monolayer
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