Name: Preparation of a Corannulene-functionalized Hexahelicene by Copper(I)-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units (Video) | JoVE Journal
Uploaded: 2016-09-18T14:00:00.000+00:00
Duration: 9 min 35 s
Description: Learn to synthesize corannulene-functionalized hexahelicene using copper(I)-catalyzed alkyne-azide cycloaddition. This six-step protocol employs click chemistry to assemble nonplanar polyaromatic units with reasonable yields.

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5 minutes

This work was funded by the Spanish Ministerio de Econom&#236;a y Competitividad (CTQ 2013-41067-P). H.B. acknowledge with thanks a MEC-FPI grant.

1. Functionalization of 2,15-Dimethylhexahelicene
<ol>
	<li>Dibromination of 2,15-dimethylhexahelicene
	<ol>
		<li>Weigh 0.356 g (1.0 mmol) of 2,15-dimethylhexahelicene, 0.374 g (2.1 mmol) of freshly recrystallized N-bromosuccinimide (NBS) and 24 mg (0.07 mmol) of benzoyl peroxide (BPO) (70% wt with 30% of water as stabilizer). Place all solids in a 100 ml Schlenk flask with a magnetic stir bar. Put under nitrogen atmosphere by three cycles of gas evacuation followed by refilling with inert gas in the Schlenk line.</li>
		<li>Add 21 ml of carbon tetrachloride (CCl4). Degas the solution by the same evacuation/refilling process (step 1.1.1) with vigorous stirring and carefully in order to prevent massive loss of solvent.</li>
		<li>Heat at reflux (77 °C) the mixture with an oil bath for 4 hours. Check the reaction by 1H-nuclear magnetic resonance (NMR). Doublets between 3.7 ppm and 4.0 ppm should appear. They indicate the presence of diastereotopic -CH2- groups (Figure 1).</li>
		<li>Once finished, cool the mixture to room temperature and remove the solvent under vacuum. Set up a trap filled with liquid nitrogen to avoid pump contamination.</li>
		<li>Redissolve the crude in 30 ml of dichloromethane (DCM), transfer to a round-bottom flask and mix with 4 g of silica gel (typically add 5-fold the crude weight). Concentrate the mixture in a rotary evaporator.</li>
		<li>In the meantime, fill a column (length around 20 cm and a thickness of 4.5 cm) with SiO2 gel mixed previously with hexane/ethyl acetate (95:5) as the mobile phase. Add the mixture to the top of the column and then add a layer of sand (2 cm).</li>
		<li>Carefully pour in the new mobile phase and perform the chromatography by collecting fractions in test tubes (typically 20 ml per tube and 4 ml near the expected product elution). Check fractions by thin layer chromatography (TLC) with the same mobile phase (hexane/ethyl acetate 95:5) and image under UV light. The expected product (4b) should elute at a Retention factor (Rf) of 0.35 as a yellow oil after combining all wanted fractions and removing off the solvent in the rotary evaporator. 334 mg should be obtained (yield 65%). 
		NOTE: All Schlenk techniques, the use of an oil bath for heating and column chromatography settings will be widely utilized in most of the protocols, so from now on, they will not be covered in detail and only a few comments, when necessary, will be given.</li>
	</ol>
	</li>
</ol>
<img alt="NMR spectra, chemical structure analysis, peaks at specific ppm levels, spectroscopy results." src="/files/ftp_upload/53954/53954fig1.jpg" data-altupdatedat="1788235205000" data-alt="Figure 1"> 
Figure 1. 1H-NMR spectra (500 MHz, CDCl3) of 2,15-dimethylhelicene (top) and an aliquot taken after 2 hr. New signals, corresponding to -CH2-, are depicted in a red circle (bottom). <a href="https://www.jove.com/files/ftp_upload/53954/53954fig1large.jpg" target="_blank">Please click here to view a larger version of this figure.</a>
<ol start="2">
	<li>Synthesis of 2,15-bis(azidomethyl)hexahelicene
	<ol>
		<li>Weigh 0.103 g (0.2 mmol) of 2,15-bis(bromomethyl)hexahelicene and 0.390 g (6 mmol) of sodium azide. Place both solids in a 50 ml Schlenk flask equipped with magnetic bar and put under nitrogen atmosphere.</li>
		<li>Mix 8.6 ml of tetrahydrofuran (THF) with 5.2 ml of water (H2O) and pour the mixture of solvents into the Schlenk flask. Degas the solution.</li>
		<li>Heat at reflux (65 °C) for 3 hr. Check the reaction by 1H-NMR. -CH2- signals should shift to 3.75 ppm (Figure 2).</li>
		<li>Afterwards, cool down the mixture to room temperature and remove THF under vacuum. Dilute with 50 ml of H2O.</li>
		<li>Transfer the mixture to a separatory funnel and extract three times with 40 ml of DCM. Combine all organic phases and wash with pure H2O (50 ml).</li>
		<li>Purify the crude by column chromatography on silica gel using hexane/ethyl acetate (85:15) as the mobile phase to give a yellow oil at Rf=0.38 corresponding to 2,15-bis(azomethyl)hexahelicene (5b). 70 mg should be obtained (yield 80%).</li>
	</ol>
	</li>
</ol>
<img alt="NMR spectrum diagram, displaying chemical shift peaks for molecular structure analysis." src="/files/ftp_upload/53954/53954fig2.jpg" data-altupdatedat="1788235205000" data-alt="Figure 2"> 
Figure 2: 1H-NMR spectra (500 MHz, CDCl3) of 4b (top) and an aliquot taken after 3 hr (bottom). Note the changes in the aliphatic region. <a href="https://www.jove.com/files/ftp_upload/53954/53954fig2large.jpg" target="_blank">Please click here to view a larger version of this figure.</a>
2. Functionalization of Corannulene
<ol>
	<li>Monobromination of Corannulene
	<ol>
		<li>Weigh 0.125 g (0.5 mmol) of corannulene, 89 mg (0.5 mmol) of freshly recrystallized NBS and 17 mg of gold(III) chloride hydrate.</li>
		<li>Place all compounds into a 10 ml vial specially designed for microwave reactions equipped with a magnetic bar and then put into a nitrogen atmosphere with the help of a 2-necked round-bottom flask.</li>
		<li>Add 7 ml of 1,2-dichloroethane (DCE) and degas the solution.</li>
		<li>Sonicate the mixture for 2 min to disperse gold salt particles.</li>
		<li>Heat inside the microwave reactor at 100 °C for 2 hr.</li>
		<li>When finished, transfer the crude to a round-bottom flask and remove solvent by rotary evaporation.</li>
		<li>Purify the crude by column chromatography on SiO2 gel using hexane as mobile phase. 
		NOTE: Bromocorannulene (4a) is obtained as a yellow solid at Rf=0.38. 99 mg should be obtained (yield 60%). Unreacted corannulene (3a) can be recovered and stored for further uses. It appears at Rf=0.29.</li>
	</ol>
	</li>
	<li>Sonogashira Coupling of Bomocorannulene and Ethynyltrimethylsilane
	<ol>
		<li>Weigh 49 mg (0.15 mmol) of bromocorannulene, 11 mg (0.015 mmol) of [PdCl2(dppf)]49,50 (dppf being 1,1-'bis(diphenylphsphino)ferrocene, 3 mg (0.015 mmol) of CuI.51</li>
		<li>Place all solids in a 50 ml Schlenk flask along with a magnetic bar and put under nitrogen atmosphere.</li>
		<li>Add 5.0 ml of triethylamine (NEt3) and degas the mixture.</li>
		<li>Finally, add 104 µl (0.75 mmol) of ethynyltrimethylsilane.</li>
		<li>Sonicate the mixture for 2 min to disperse metal salt particles.</li>
		<li>Heat at 85 °C for 24 hr with periodic sonication to prevent deposition of metal salts. 
		NOTE: The mixture color turned to black soon, indicating the presence of palladium(0).</li>
		<li>Cool down to room temperature and evaporate NEt3 in vacuo.</li>
		<li>Redissolve in 20 ml of DCM and purify by column chromatography on silica gel eluting with hexane to give a yellow solid at Rf=0.28 corresponding to 5a. 41 mg should be obtained (yield 78%). 
		NOTE: If the crude is filtered through a Celite pad in DCM, a reasonable pure sample might be obtained, however phosphine derivatives are not removed totally.</li>
	</ol>
	</li>
	<li>Preparation of Ethynylcorannulene by TMS Deprotection
	<ol>
		<li>Weigh 35 mg (0.10 mmol) of 5a and 7.3 mg (0.125 mmol) of anhydrous potassium fluoride.</li>
		<li>Place all solids in a 50 ml Schlenk flask equipped with a magnetic bar and put under nitrogen atmosphere.</li>
		<li>Mix 4 ml of THF and 4 ml of methanol (MeOH) and pour the mixture into the Schlenk flask. Degas thoroughly.</li>
		<li>Allow to react at room temperature, Keep the flask away from light by covering it with an opaque film. Check the reaction by 1H-NMR by looking at 3.48 ppm. A signal corresponding to -CCH must emerge (Figure 3). 
		NOTE: Although this compound bears a terminal alkyne that is reactive and decomposes easily, we found no problems during the work up described below. It was carried out under natural light.</li>
		<li>Once finished, remove THF under vacuum and dilute with 10 ml of water, transferring everything to a separatory funnel.</li>
		<li>Extract with DCM (3 x 15 ml), combine all organic phases in a round-bottom flask and concentrate in a rotary evaporator at room temperature to finally get a yellow solid corresponding to 6a. 27 mg should be obtained (quantitative yield).</li>
	</ol>
	</li>
</ol>
<img alt="NMR spectroscopy chart illustrating chemical shift; peak analysis for molecular identification." src="/files/ftp_upload/53954/53954fig3.jpg" data-altupdatedat="1788235205000" data-alt="Figure 3"> 
Figure 3: 1H-NMR spectra (500 MHz, CDCl3) of 5a (top) and 6a (bottom). -CCH singlet is depicted in a red circle. <a href="https://www.jove.com/files/ftp_upload/53954/53954fig3large.jpg" target="_blank">Please click here to view a larger version of this figure.</a>
3. Final Assembly by Click Chemistry
<ol>
	<li>Weigh 15.3 mg (0.035 mmol) of 5b, 20.0 mg (0.073 mmol) of 6a, 1.4 mg (0.007 mmol) of ascorbic acid sodium salt, 1.7 mg (0.007 mmol) of CuSO4·5H2O.</li>
	<li>Place all solids in a 50 ml Schlenk flask equipped with a magnetic bar and put under nitrogen atmosphere.</li>
	<li>Mix 3 ml of H2O and 12 ml of THF and pour the mixture into the Schlenk flask. Degas the solution thoroughly.</li>
	<li>Heat at 65 °C for 3 days with a condenser connected to the top of the flask and check periodically the reaction to control temperature, stirring and solvent volume. Check the reaction by 1H-NMR. The signal at 3.48 ppm should disappear and be shifted to 7.27 ppm indicating the consumption of ethynyl corannulene and the existence of the triazole unit (Figure 4).</li>
	<li>When finished, remove THF under vacuum and dilute with 20 ml of water, transferring the mixture to a separatory funnel.</li>
	<li>Extract with DCM (3 x 20 ml), combine all organic phases in a round-bottom flask and concentrate in a rotary evaporator.</li>
	<li>Purify the crude by column chromatography on SiO2 gel eluting with hexane/ethyl acetate (1:1) to give a pale yellow solid at Rf = 0.59 corresponding to 7. 27 mg should be obtained (yield 75%).</li>
</ol>
<img alt="NMR spectra diagram displaying chemical shifts for structural analysis; includes peak identification." src="/files/ftp_upload/53954/53954fig4.jpg" data-altupdatedat="1788235205000" data-alt="Figure 4"> 
Figure 4: 1H-NMR spectra (500 MHz, CDCl3) of 5b (top), 6a (middle) and an aliquot taken after 2 days (bottom). Note the disappearance of -CCH signal in the crude. <a href="https://www.jove.com/files/ftp_upload/53954/53954fig4large.jpg" target="_blank">Please click here to view a larger version of this figure.</a>

The authors have nothing to disclose.

Final compound 7 has been prepared after 6 steps from nonplanar polyaromatic precursors 3a and 3b with moderate to very good yields at each reaction. The main limitation observed in this route was the bromination of both nonplanar polyaromatic compounds. However, in the case of compound 4a, an important amount of free corannulene can be recovered for further uses. The synthesis of 4<stro...

Due to their special geometry, corannulene and helicenes are molecules that can adopt a structure far from planarity and give rise to interesting properties.1-15 In the last few years, the search of molecular receptors for carbon nanotubes and fullerenes is a very active area16-19 due, mainly, to their potential applications as materials for organic solar cells, transistors, sensors and other devices.20-28 The excellent complementarity in shape between corannulene and a fullerene have attracted the attention of several researchers with the aim of designing molecular receptors capable of establishing supramolecular association by dispersion forces.29-39
The chemistry of the above mentioned nonplanar polyaromatic compounds is similar to that described for totally planar molecules, but it is sometimes difficult to find suitable conditions to achieve desired selectivities and yields.40 In this work we present the synthesis of a molecule (7) having three polyaromatic units in a few steps with good yields by applying easy and typical techniques found in every research laboratory. The molecule is of great importance because it can adopt a pincer-like conformation to establish good interactions with C6037 in solution; and it may open a research line as a potential receptor for higher chiral fullerenes thanks to the helicene linker, which is a chiral molecule due to the existence of a stereogenic axis.41-45 However, only racemic helicene will be used in this work.
At this point, the only limitation to synthesize these receptors is the preparation of helicenes and corannulenes, since they are not commercially available. But, according to new methods published elsewhere46-48 they can be obtained in suitable amounts in a reasonable short period of time.

<table><tbody><tr><td>2,15-Dimethylhexahelicene</td><td>N/A</td><td>N/A</td><td>Prepared according to reference 5b,c in the main text.</td></tr><tr><td>Corannulene</td><td>N/A</td><td>N/A</td><td>Prepared according to reference 5a in the main text.</td></tr><tr><td>&lt;em&gt;N&lt;/em&gt;-Bromosuccinimide (NBS)</td><td>Sigma Aldrich</td><td>B8.125-5</td><td>ReagentPlus&amp;reg;, 99%. Recrystallized from hot water.</td></tr><tr><td>Benzoyl peroxide (BPO)</td><td>Sigma Aldrich</td><td>B-2030</td><td>~70% (titration). 30% water as stabilizer.</td></tr><tr><td>Sodium azide</td><td>Sigma Aldrich</td><td>S2002</td><td>ReagentPlus&amp;reg;, &amp;ge;99.5%.</td></tr><tr><td>Gold(III) chloride Hydrate</td><td>Sigma Aldrich</td><td>50778</td><td>puriss. p.a., ACS reagent, &amp;ge;49% Au basis.</td></tr><tr><td>Ethynyltrimethylsilane</td><td>Sigma Aldrich</td><td>218170</td><td>98%</td></tr><tr><td>[PdCl&lt;sub&gt;2&lt;/sub&gt;(dppf)]</td><td>N/A</td><td>N/A</td><td>Prepared according to reference 6 in the main text.</td></tr><tr><td>CuI</td><td>N/A</td><td>N/A</td><td>Prepared according to reference 7 in the main text.</td></tr><tr><td>KF</td><td>Sigma Aldrich</td><td>307599</td><td>99%, spray-dried.</td></tr><tr><td>(+)-Sodium L-ascorbate</td><td>Fluka</td><td>11140</td><td>BioXtra, &amp;ge;99.0% (NT).</td></tr><tr><td>Copper(II) Sulphate 5-hydrate</td><td>Panreac</td><td>131270</td><td>For analysis.</td></tr><tr><td>Carbon tetrachloride (CCl&lt;sub&gt;4&lt;/sub&gt;)</td><td>Fluka</td><td>87030</td><td>For IR spectroscopy, &amp;ge;99.9%.</td></tr><tr><td>Dichloromethane (DCM)</td><td>Fisher Scientific</td><td>D/1852/25</td><td>Analytical reagent grade. Distilled prior to use.</td></tr><tr><td>Hexane</td><td>Fisher Scientific</td><td>H/0355/25</td><td>Analytical reagent grade. Distilled prior to use.</td></tr><tr><td>Ethyl acetate</td><td>Scharlau</td><td>AC0145025S</td><td>Reagent grade. Distilled prior to use.</td></tr><tr><td>Tetrahydrofuran (THF)</td><td>Fisher Scientific</td><td>T/0701/25</td><td>Analytical reagent grade. Distilled prior to use.</td></tr><tr><td>1,2-Dichloroethane (DCE)</td><td>Sigma Aldrich</td><td>D6,156-3</td><td>ReagentPlus&amp;reg;, 99%.</td></tr><tr><td>Methanol (MeOH)</td><td>VWR</td><td>20847.36</td><td>AnalaR NORMAPUR.</td></tr><tr><td>Triethyl amine (NEt&lt;sub&gt;3&lt;/sub&gt;)</td><td>Sigma Aldrich</td><td>T0886</td><td>&amp;ge;99%</td></tr><tr><td>Silica gel</td><td>Acros</td><td>360050010</td><td>Particle size 40-60 mm.</td></tr><tr><td>Sand - low iron</td><td>Fisher Scientific</td><td>S/0360/63</td><td>General purpose grade.</td></tr><tr><td>TLC Silica gel 60 F&lt;sub&gt;254&lt;/sub&gt;</td><td>Merck</td><td>1.05554.0001</td><td></td></tr><tr><td>Monowave 300 (Microwave reactor)</td><td>Anton Para</td><td></td><td></td></tr><tr><td>Sonicator</td><td>Grupo Selecta</td><td>3000513</td><td>6 Litres.</td></tr></tbody></table>

preparation of a corannulene-functionalized hexahelicene by copper(i)-catalyzed alkyne-azide cycloaddition of nonplanar polyaromatic units

Preparation of a Corannulene-functionalized Hexahelicene by Copper(I)-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

The main purpose of this video is to show 6 reaction steps of a convergent synthesis and prepare a complex molecule containing up to three nonplanar polyaromatic units, which are two corannulene moieties and a racemic hexahelicene linking them. The compound described in this work is a good host for fullerenes. Several common organic reactions, such as free-radical reactions, C-C coupling or click chemistry, are employed demonstrating the versatility of functionalization that this compound can accept. All of these reactions work for planar aromatic molecules. With subtle modifications, it is possible to achieve similar results for nonplanar polyaromatic compounds.

Corannulene (3a) and 2,15-dimethylhexahelicene (3b) could be prepared following current methods46-48 in a straightforward fashion with very good yields (Figure 5). Both share a common molecule, 2,7-dimethylnaphthalene, as the starting material, giving rise to a divergent to convergent synthesis of the final molecule.
<img alt="Ch...

Here, we present a protocol to synthesize a complex organic compound comprised of three nonplanar polyaromatic units, assembled easily with reasonable yields.

The main purpose of this video is to show 6 reaction steps of a convergent synthesis and prepare a complex molecule containing up to three nonplanar ...

The overall goal of this protocol is to synthesize a corannulene functionalized hexahelicene, a complex organic compound comprised of three nonplanar polyaromatic units assembled by click chemistry. The method consists of a set of six reactions steps in a synthesis by using several common organic procedures. Such as free radical reactions, carbon carbon coupling, or click chemistry.The main advantage of this method is that with subtle modification of these well known reactions, it is possible to achieve similar results for a nonplanar polyaromatic compounds. This method can provide insight into the chemistry of this special family. Because its behavior is not so similar to that of planar aromatic compounds it can also be applied to systems such as extended tetrathiafulvalene or 7 annulene.We first had an idea for this protocol on our work dealing with host guest recognition when trying to assemble two chorionic units into helicine scaffold. To begin the debromination weigh o. 356g of 2, 15 dimethylhexyl helicene, 374g of freshly recrystallized n bromosuccinimide and 24mg of benzoyl peroxide.Place all solids in a 100ml schlenk flask with a magnetic stir bar. Put the solids under nitrogen atmosphere by three cycles of gas evacuation followed by refilling with inert gas in the schlenk line. Then add 21ml of carbon tetrachloride.Degas the solution by the same evacuation and refilling process with vigorous stirring. Take care to prevent massive loss of the solvent. Reflux the mixture at 77 degrees Celsius, using an oil bath for four hours.The reaction can be followed by proton nuclear magnetic resonance or NMR spectroscopy. Doublets between 3.7 parts per million and 4.0 parts per million should appear indicating the presence of diastereotopic methylene groups. Once finished, cool the mixture to room temperature and remove the solvent under vacuum.Set up a trap filled with liquid nitrogen to avoid pump contamination. Redissolve the crude in 30ml of dichloromethane. Then transfer the solution to a round bottom flask and mix with 4g of silica gel.Concentrate the mixture in a rotary evaporator. In the meantime, fill a column with silica gel mixed previously with hexane ethyl acetate as the mobile phase. Add the mixture to the top of the column and then add a 2cm layer of sand.Carefully pour in the new mobile phase. Perform the chromatography by collecting fractions in test tubes at 20ml per tube and 4ml per tube near the expected product solution. Check the fractions by thin layer chromatography with the same mobile phase and image under ultra violet light.The expected product should elute at a retention factor of 0.35 as a yellow oil after combining all the desired fractions and removing the solvent in the rotary evaporator. To perform the synthesis, weigh 0.103g of 2, 15 bis bromomethyl hexahelicene and 0.390g of sodium azide. Place both solids in a 50ml schlenk flask equipped with a magnetic stir bar and put under a nitrogen atmosphere.Then mix 8.6ml of tetrahydrofuran with 5.2ml of water and pour the mixture of solvents into the schlenk flask. After degassing the solution, reflux at 65 degrees Celsius for three hours. Check the reaction by proton NMR.Methylene group signals should shift to 3.75 parts per million. Afterwards cool down the mixture to room temperature and remove the tetrahydrofuran under a vacuum. Then dilute the sample with 50ml of water.Tranfser the mixture to separatory funnel and extract three times with 40ml of dicholoromethane. Combine all organic phases and wash with 50ml of distilled water. Purify the crude by column chromatography on silica gel using hexane ethylacetate as the mobile phase to give a yellow oil at a retention factor of 0.38.Corresponding to 2, 15 bis asomethylhexahelicine. 70mg should be obtained, which corresponds to a yield of 80%At this point in the procedure, there are three additional steps to obtain a ethinyl carnoline. The reactions involve a microwave assisted electrophilic aromatic substitution followed by sonogashira coupling and a subsequent deep protection.All these procedures are detailed in the text protocol. Weigh 15.3mg of two 15 bis asomethylhexahelicine, 20.0mg of ethinyl carnoline, 1.4mg of ascorbic acid sodium salt and 1.7mg of copper two sulfate pentahydrate. Place all solids in a 50ml schlenk flask equipped with a magnetic bar and put under a nitrogen atmosphere.A very critical step is to degas the mixture of solvents thoroughly. Mix 3ml of water and 12ml of tetrahydrofuran and pour the mixture into the schlenk flask. Degas the solution thoroughly.A second important point is to check the reaction periodically to ensure good solvent volume and temperature. Otherwise the reaction may require a longer time ethynil composition. Heat at 65 degrees Celsius for three days with a condensor connected to the top of the flask.Check the reaction periodically to control temperature, stirring and solvent volume. Check the reaction by proton NMR. The signal at 3.48 parts per million should disappear and be shifted to 7.27 parts per million indicating the consumption of ethinyl carnoline and the existence of the triazol unit.When finished, remove the tetrahydrofuran under vacuum and dilute with 20ml of water. Transferring the mixture to a separatory funnel and rinsing the flask with 20ml of dichloromethane. After extracting the mixture three times with dicholormethane, combine all organic phases in a round bottom flask and concentrate in a rotary evaporator.Purify the crude by column chromatography on silica gel eluting with hexane ethyl acetate to get the pale yellow solid at a retention factor of 0.59.27mg should be obtained corresponding to yield of 75%Carnoline and 2, 15 dimethylhexahelicine can be prepared following current methods in a straightforward fashion with very good yields. Both reaction pathways share a common molecule. 2, 7 dimethylnaphthalene as the starting material.According to the present synthetic route, the final compound was prepared within six steps from the molecules mentioned, giving rise to a divergent to convergent synthesis. Final assembly relies on the famous strategy of copper 1 catalyzed azide alkine cyclo addition known as the click reaction. Following this procedure, a complex organic molecule capable of establishing super molecular interactions with fullerenes can be prepared in reasonable times and with good yeilds.After watching this video you should have a good understanding of how to apply successfully known reactions in traditional organic chemistry to build a multi step view towards complex non planar poly aromatic molecules with interesting properties.

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Learn to synthesize corannulene-functionalized hexahelicene using copper(I)-catalyzed alkyne-azide cycloaddition. This six-step protocol employs click chemistry to assemble nonplanar polyaromatic units with reasonable yields.

Preparation of a Corannulene-functionalized Hexahelicene by Copper(I)-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units (Video) | JoVE Journal

Preparation of a Corannulene-functionalized Hexahelicene by Copper(I)-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

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