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Developmental Biology

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Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration
 

Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration

Article doi: 10.3791/53973
May 19th, 2016

Summary May 19th, 2016

MRP4 regulates various cyclic nucleotide-dependent signaling events including a recently elucidated role in cell migration. We describe a direct, but multifaceted approach to unravel the downstream molecular targets of MRP4 resulting in identification of a unique MRP4 interactome that plays key roles in the fine-tuned regulation of fibroblast migration.

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