Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

Mianbo Huang; Jin Xu; Chong Hyun Shin

doi:10.3791/54002

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Desenvolvimento de um modelo de fígado fibrótica induzida por etanol no peixe-zebra para estudar Progenitor mediada por células de regeneração de hepatócitos

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

JoVE Journal
Developmental Biology

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JoVE Journal Developmental Biology

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

Desenvolvimento de um modelo de fígado fibrótica induzida por etanol no peixe-zebra para estudar Progenitor mediada por células de regeneração de hepatócitos

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9,116 Views

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10:42 min

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May 13, 2016

DOI:

10.3791/54002-v

DOI:

10.3791/54002-v

•

10:42 min

May 13, 2016

•

6 Views

Mianbo Huang¹, Jin Xu¹, Chong Hyun Shin¹

¹School of Biology, Parker H. Petit Institute for Bioengineering and Bioscience,Georgia Institute of Technology

Transcript

Summary

Sustained fibrosis with deposition of excessive extracellular matrix proteins leads to cirrhosis. Alcohol abuse is one of the main causes of severe liver disease. We established an ethanol-induced zebrafish fibrotic liver model to study the mechanisms and strategies of promoting hepatocyte regeneration upon alcohol-induced injury.