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07:57 min
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June 21, 2016
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Summary
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Surgical induction of hindlimb ischemia in the mouse is useful to examine angiogenesis, however this is compromised in certain inbred mouse strains that display marked ischemia-induced tissue necrosis. Methods are described to induce subacute limb ischemia using ameroid constrictors to circumvent this problem through the induction of gradual arterial occlusion.
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Cite this Article
Padgett, M. E., McCord, T. J., McClung, J. M., Kontos, C. D. Methods for Acute and Subacute Murine Hindlimb Ischemia. J. Vis. Exp. (112), e54166, doi:10.3791/54166 (2016).
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