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JoVE Journal
Bioengineering

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Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
 

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Article doi: 10.3791/54202
August 22nd, 2016

Summary August 22nd, 2016

Self-assembled polyelectrolyte complexes (PEC) fabricated from heparin and protamine were deposited on alginate beads to entrap and regulate the release of osteogenic growth factors. This delivery strategy enables a 20-fold reduction of BMP-2 dose in spinal fusion applications. This article illustrates the benefits and fabrication of PECs.

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