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JoVE Journal
Bioengineering

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In Vitro Permeation of FITC-loaded Ferritins Across a Rat Blood-brain Barrier
 

In Vitro Permeation of FITC-loaded Ferritins Across a Rat Blood-brain Barrier: a Model to Study the Delivery of Nanoformulated Molecules

Article DOI: 10.3791/54279
August 22nd, 2016

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Summary August 22nd, 2016

A method to establish an in vitro model of blood-brain barrier based on a co-culture of rat brain microvascular endothelial cells and astrocytes is described and validated. This system proved to be a valid tool to study the effect of nanoformulation on the trans-barrier permeation of fluorescent molecules.

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