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JoVE Journal
Biochemistry

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Automated Acoustic Dispensing for the Serial Dilution of Peptide Agonists in Potency Determination Assays
 

Automated Acoustic Dispensing for the Serial Dilution of Peptide Agonists in Potency Determination Assays

Article DOI: 10.3791/54542
November 10th, 2016

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Summary November 10th, 2016

Peptide adsorption to plasticware during traditional tip-based serial dilutions can significantly impact potency determination and confound the understanding of structure-activity relationships used for lead identification and lead optimization phases of drug discovery. Here methods for automated acoustic non-contact serial dilution of peptide samples are described.

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