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An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment
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An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment

Article DOI: 10.3791/54619-v • 09:33 min • September 13th, 2016
September 13th, 2016 •
1, 2, 2, 1,2
1Graduate School of Biomedical Sciences, Rowan University, 2Department of Cell Biology, Rowan University School of Osteopathic Medicine

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Summary
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A low-cost, easy-to-use and powerful system is established to evaluate potential treatments that could ameliorate blood retinal barrier breach induced by histamine. Blood vessel leakage, Müller cell activation and the continuity of neuronal processes are utilized to assess the damage response and its reversal with a potential drug, lipoxin A4.

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Retinal Model Blood Retinal Barrier Breach Drug Treatment Ex Vivo Model Neural Degenerative Diseases Early Events Drug Screening Low-cost Easy To Use Fast Adaptable Technical Skills Swine Retinas Procurement Dissection Vitreous Humor Optic Disc Optic Nerve Petri Dish HBSS
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