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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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JoVE Journal Immunology and Infection
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

DOI:
10.3791/54720-v

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10:10 min

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November 08, 2016

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, , ,
1Department of Microbiology and Immunology,The Pennsylvania State University College of Medicine

Chapters

  • 00:05Title
  • 00:43In Vitro Antigen-specific Inducible Pluripotent Stem Cell (iPSC)-T Regulatory Cell (T-reg) Differentiation
  • 04:00In Vivo iPSC Maturation and Autoimmune Arthritis Suppression and Analysis
  • 06:24Results: Representative Antigen-specific iPSC-T-reg Mediated Arthritis Suppression
  • 08:54Conclusion

Summary

Automatic Translation

Automatic Translation

We present here a method to develop functional antigen (Ag)-specific regulatory T cells (Tregs) from induced pluripotent stem cells (iPSCs) for immunotherapy of autoimmune arthritis in a murine model.

Tags

Keywords: Stem CellRegulatory T CellsAutoimmune ArthritisImmunotherapyAntigen-specificInduced Pluripotent Stem Cells (iPSCs)OP9 Feeder CellsFlt3-LigandIL-7

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