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Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

DOI:
10.3791/54760-v

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06:32 min

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October 24, 2016

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, , , , ,
1Clinic for Surgery and Small Animals, Veterinary Faculty,University of Ljubljana, 2Department of Experimental Oncology,Institute of Oncology Ljubljana, 3Faculty of Health Sciences,University of Primorska, 4IPBS (Institut de Pharmacologie et de Biologie Structurale),CNRS, 5IPBS (Institut de Pharmacologie et de Biologie Structurale),Université de Toulouse

Chapters

  • 00:00Title
  • 00:16Introduction
  • 01:01Preparation
  • 02:31Administration of Cisplatin and Application of Electric Pulses
  • 04:14Results: Follow up 1 Week
  • 04:30Results: Follow up 1 Month
  • 05:11Conclusion

Summary

Automatic Translation

Automatic Translation

Electrochemotherapy is the local treatment of solid tumors. The main mechanism is electroporation-mediated permeabilization of the tumor cells' membrane which enables increased internalization of cytostatics like bleomycin and cisplatin. Thus, antitumor effectiveness is potentiated at the site of the application of electric pulses to the tumors.

Tags

Keywords: ElectrochemotherapyTumor TreatmentDogsCatsCytostatic DrugsElectroporationBleomycinCisplatinIntratumoral InjectionIntravenous InjectionElectric PulsesPlate ElectrodesNeedle ElectrodesVasoconstrictionDrug Retention

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