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JoVE Journal
Developmental Biology

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Chondrogenic Differentiation Induction of Adipose-derived Stem Cells by Centrifugal Gravity
 

Chondrogenic Differentiation Induction of Adipose-derived Stem Cells by Centrifugal Gravity

Article DOI: 10.3791/54934
February 24th, 2017

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Summary February 24th, 2017

Mechanical stress can induce the chondrogenic differentiation of stem cells, providing a potential therapeutic approach for the repair of impaired cartilage. We present a protocol to induce the chondrogenic differentiation of adipose-derived stem cells (ASCs) using centrifugal gravity (CG). CG-induced upregulation of SOX9 results in the development of chondrogenic phenotypes.

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