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An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage
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Bioengineering
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JoVE Journal Bioengineering
An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage

DOI:
10.3791/54984-v

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07:57 min

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April 23, 2017

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, , ,
1Department of Biomechanical Engineering, Faculty of Mechanical, Maritime, and Materials Engineering,Delft University of Technology (TU Delft), 2Department of Orthopedics,UMC Utrecht, 3Department of Rheumatology,UMC Utrecht

Chapters

  • 00:05Title
  • 00:46Sample Preparation and Imaging
  • 03:22Computational Modeling
  • 06:38Results: Axial Solute Diffusion through Articular Cartilage
  • 07:19Conclusion

Summary

Automatic Translation

Automatic Translation

We propose a protocol to investigate the transport of charged and uncharged molecules across articular cartilage with the aid of recently developed experimental and numerical methods.

Tags

Keywords: Articular CartilageSolute TransportDiffusion CoefficientFixed Charge DensityMicrocomputer TomographyIoxaglateIodixanolContrast Agent3D ImagingImage SegmentationConcentration MeasurementFinite Element Analysis

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