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Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension
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Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension

Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension

DOI:
10.3791/55065-v

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09:23 min

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February 11, 2017

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, , , , , ,
1Center for Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children’s Hospital,University Medical Center Groningen, University of Groningen, 2Research and Development Facility,University Medical Center Groningen, University of Groningen

Chapters

  • 00:05Title
  • 01:21Aorto-caval Shunt Surgery
  • 04:21Right Heart Catheterization
  • 07:01Results: Representative Pulmonary Hemodynamics and Vascular Morphology/Morphometry Analyses
  • 08:29Conclusion

Summary

Automatic Translation

Automatic Translation

This protocol describes a surgical procedure to create a model for flow-induced pulmonary arterial hypertension (PAH) in rats and the procedures to analyze the principle hemodynamic and histological end-points in this model.

Tags

Keywords: Shunt SurgeryRight Heart CatheterizationVascular MorphometryRat ModelFlow-induced Pulmonary Arterial HypertensionPulmonary HypertensionIntimal-type Vascular RemodelingPulmonary Blood FlowHemodynamic EvaluationHistopathologyQuantitative MorphometryTreatment StrategiesPulmonary HemodynamicsVascular MorphologyMicrosurgeryAnesthesiaBuprenorphineMidline IncisionAbdominal AortaVena Cava InferiorPerivascular Aortic FatBeamer ClampKocher Clamp18 Gauge Needle

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