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Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms
This content is Free Access.
1Biomedical Engineering Graduate Program,The University of Western Ontario, 2Department of Anatomy & Cell Biology, Schulich School of Medicine & Dentistry,The University of Western Ontario, 3Department of Chemical Engineering,Queen’s University, 4Department of Chemical & Biochemical Engineering, Faculty of Engineering,The University of Western Ontario
Chapters
- 00:05Title
- 00:52Decellularized Tissue Processing
- 01:41Extracellular Matrix (ECM) Suspension Preparation
- 04:01ECM-derived Foam Fabrication
- 04:58ECM-derived Microcarrier Fabrication via Electrospraying
- 07:11Preparation of Foams and Microcarriers for Cell Culture
- 08:55Results: Fabricated ECM-derived Foams and Microcarriers
- 10:36Conclusion
The tissue-specific extracellular matrix (ECM) is a key mediator of cell function. This article describes methods for synthesizing pure ECM-derived foams and microcarriers that are stable in culture without the need for chemical crosslinking for applications in advanced 3D in vitro cell culture models or as pro-regenerative bioscaffolds.
