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JoVE Journal
Bioengineering

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Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening
 

Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening

Article doi: 10.3791/55461
April 15th, 2017

Summary April 15th, 2017

Here, we show the generation of human engineered heart tissue from induced pluripotent stem cells (hiPSC)-derived cardiomyocytes. We present a method to analyze contraction force and exemplary alteration of contraction pattern by the hERG channel inhibitor E-4031. This method shows high level of robustness and suitability for cardiac drug screening.

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