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Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology
JoVE Journal
Medicine
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JoVE Journal Medicine
Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology

Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology

DOI:
10.3791/55523-v

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10:02 min

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May 28, 2017

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, , , ,
1Hilltop Laboratory Animals, 2Preclinical Research & Development,Proclara Biosciences, Inc.

Chapters

  • 00:05Title
  • 00:58Y-Maze Working Memory Test
  • 02:37Novel Object Intermediate-term Memory Test
  • 06:01Limb Clasping Corticospinal Function Test
  • 07:25Results: Test Results
  • 09:14Concusion

Summary

Automatic Translation

Automatic Translation

Described here is a staged, behavioral screening approach that can be used to screen for compounds that exhibit in vivo efficacy on cognitive and functional motor behaviors in transgenic mouse models of β-amyloidosis and tauopathy. These methods are optimized to screen compounds for activity in short-term and working memory tasks.

Tags

Keywords: Alzheimer’s DiseaseTransgenic Mouse ModelsAmyloid-βTauSpontaneous AlternationNovel Object RecognitionLimb ClaspingPreclinical Drug DiscoveryY-mazeOpen Field ArenaBehavior AssessmentDementiaCognitive DysfunctionFrontotemporal DementiaTraumatic Brain InjuryAutism

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