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Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion
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Medicine
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JoVE Journal Medicine
Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion

Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion

DOI:
10.3791/55763-v

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08:37 min

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November 08, 2017

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, , , , , ,
1Department of Medical Physiology,Hamamatsu University School of Medicine, 2Division of Vascular Surgery, Second Department of Surgery,Hamamatsu University School of Medicine, 3Department of Applied Biological Chemistry, Graduate School of Agriculture,Kindai University, 4Department of Organ & Tissue Anatomy,Hamamatsu University School of Medicine

Chapters

  • 00:05Title
  • 01:20Model Preparation
  • 04:44Harvesting, Fixing, and Elastica-van Gieson (EVG) Staining
  • 06:33Results: Representative Live Palate Explant Culture Imaging
  • 07:21Conclusion

Summary

Automatic Translation

Automatic Translation

Polyurethane catheter insertion into the aortic lumen and suture ligation of the aorta induce chronic hypoxia due to hypoperfusion of the adventitial vasa vasorum. This article describes a novel animal model of abdominal aortic aneurysm (AAA) with characteristics similar to those of AAA in humans.

Tags

Keywords: Abdominal Aortic AneurysmRodent ModelVasa VasorumAortic DilationVascular SurgeryAortic WallRetroperitoneumVascular ClipsPolyurethane Catheter

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