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Assessing Spatial Memory Impairment in a Mouse Model of Traumatic Brain Injury Using a Radial Water Tread Maze
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Assessing Spatial Memory Impairment in a Mouse Model of Traumatic Brain Injury Using a Radial Water Tread Maze

Article DOI: 10.3791/55986-v • 06:09 min • July 17th, 2017
July 17th, 2017 •
1, 2, 3, 2, 2, 2
1Department of Radiology, University of Washington, 2Department of Radiology, University of Utah, 3Geriatric Research Education and Clinical Center (GRECC), VA Puget Sound

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Summary
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Here we present a protocol for a mouse-specific test of cognition that does not require swimming. This test can be used to successfully distinguish controlled cortical impact-induced traumatic brain injury mice from sham controls.

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Radial Water Tread Maze Spatial Memory Impairment Traumatic Brain Injury Mouse Model Cognitive Task Swimming-based Cognitive Testing Morris Water Maze Motor Deficits Lack Of Motivation Controlled Cortical Impact Model Aged Mouse Models Transgenic Mouse Models Preparatory Steps Acclimate Test Room Home Cages Round Maze Visual Cues Movable Escape Box Exit Holes Sanitation 70% Ethanol Spray Water Temperature Consistency Accurate Measurement Heating Source
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