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DOI: 10.3791/56073-v
This article describes a process for tuning the size and crosslinking density of covalently crosslinked nanoparticles from linear polyesters containing pendant functionality. By tailoring synthesis parameters (polymer molecular weight, pendant functionality incorporation, and crosslinker equivalents), a desired nanoparticle size and crosslinking density can be achieved for drug delivery applications.
The overall goal of this nanosponge synthesis technique is to understand and utilize important synthesis parameters for design and control of size in morphology. This method will help you to produce nano particles in precise dimensions and crosslinking densities for drug delivery applications. The main advantage of this technique is that it can be tailored towards different crosslinking densities of these particles and also towards different sizes of these particles and this is a very important factor in many applications where these particles will be used.
Though this method can provide insight into nanoparticle design through utilizing tailored wool synthesis parameters, it can also be applied to other polymer networks such as hydrogels and microparticles. Remove moisture from a 25 milliliter round bottom flask equipped with a magnetic stir bar as detailed in the text protocol. Once cooled, quickly remove the septum from the round bottom flask and add 2.5 milligrams of tin triflate to the very bottom of the flask, using a spatula.
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