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Establishment of a Valuable Mimic of Alzheimer’s Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein
JoVE Journal
Behavior
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JoVE Journal Behavior
Establishment of a Valuable Mimic of Alzheimer’s Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein

Establishment of a Valuable Mimic of Alzheimer’s Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein

DOI:
10.3791/56157-v

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08:27 min

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July 29, 2018

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, , , , ,
1Institute of Traditional Chinese Medicine,Chengde Medical College, 2Shijiazhuang Obstetrics and Gynecology Hospital, 3Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, 4Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, 5Institute of Basic Medical Research of Basic Medical School

Chapters

  • 00:05Title
  • 01:26Surgical Procedure
  • 04:49Morris Water Maze
  • 05:39Results: Alzheimer s Disease Model Mimicked in A-treated Group Rats
  • 06:46Conclusion

Summary

Automatic Translation

Automatic Translation

This is a protocol to mimic Alzheimer's Disease in rats by evaluation of spatial memory impairment, neuronal pathological changes, neuronal amyloid beta protein (Aβ) burden, and neurofibrillary tangles aggregation, induced by the injection of Aβ25-35 combined with aluminum trichloride and recombinant human transforming growth factor-β1.

Tags

Keywords: Alzheimer’s DiseaseRat Animal ModelIntracerebroventricular InjectionAmyloid Beta ProteinTransforming Growth Factor BetaMemory ImpairmentNeuronal DisturbanceAnimal Model EstablishmentExperimental ProtocolDrug Screening

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