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JoVE Journal
Biochemistry

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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
 

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Article doi: 10.3791/56278
September 6th, 2017

Summary September 6th, 2017

Mismatches in human leukocyte antigen (HLA) sequences between organ donor and recipient pairs are the major cause of antibody-mediated rejection in organ transplantation. Here we present the use of custom antigen arrays that are based on individual donors' HLA sequences to probe anti-donor HLA alloantibodies in organ recipients.

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