Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Jingfeng Wang; Zhenning Nie; Haiyan Chen; Xianhong Shu; Zhaohua Yang; Ruiming Yao; Yangang Su; Junbo Ge

doi:10.3791/56439

/

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

JoVE Journal
Biology

A subscription to JoVE is required to view this content. Sign in or start your free trial.

JoVE Journal Biology

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

10,446 Views

•

12:45 min

•

December 11, 2017

DOI:

10.3791/56439-v

DOI:

10.3791/56439-v

•

12:45 min

December 11, 2017

•

10430 Views

Jingfeng Wang*¹, Zhenning Nie*¹, Haiyan Chen*², Xianhong Shu², Zhaohua Yang³, Ruiming Yao¹, Yangang Su¹, Junbo Ge¹

¹Department of Cardiology, Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital, Fudan University ²Department of Echocardiography, Shanghai Institute of Medical imaging, Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital, Fudan University ³Department of Cardiac surgery, Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital, Fudan University

Summary

The establishment of a chronic asynchronous heart failure (HF) model by rapid pacing combined with left bundle branch ablation is presented. Two-dimensional speckle tracking imaging and aortic velocity time integral are applied to validate this stable HF model with left ventricular asynchrony and the benefits of cardiac resynchronization therapy.