The establishment of a chronic asynchronous heart failure (HF) model by rapid pacing combined with left bundle branch ablation is presented. Two-dimensional speckle tracking imaging and aortic velocity time integral are applied to validate this stable HF model with left ventricular asynchrony and the benefits of cardiac resynchronization therapy.
Wang, J., Nie, Z., Chen, H., Shu, X., Yang, Z., Yao, R., Su, Y., Ge, J. Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing. J. Vis. Exp. (130), e56439, doi:10.3791/56439 (2017).