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A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
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Medicine
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JoVE Journal Medicine
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

DOI:
10.3791/56701-v

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08:17 min

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February 27, 2018

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, , ,
1Department of Anesthesiology,Duke University Medical Center, 2Department of Orthopaedic Surgery,Duke University Medical Center, 3Duke Molecular Physiology Institute, 4Center for Translational Pain Medicine,Duke University Medical Center

Chapters

  • 00:05Title
  • 00:50Preoperative Setup for Parabiosis and Orthopedic Surgery
  • 01:48Parabiosis Surgery
  • 04:02Tibial Fracture Surgery
  • 06:23Results: Parabiosis Surgery Leads to Rejuvenation of Fracture Healing, Blood-sharing, and Donor-cell Engraftment
  • 07:36Conclusion

Summary

Automatic Translation

Automatic Translation

This protocol describes a mouse model of orthopedic surgery that has been used to study mechanisms of postoperative neuroinflammation and behavioral changes, and when combined with parabiosis, to study tissue regeneration during aging.

Tags

Keywords: Orthopedic SurgeryParabiosisPostoperative Cognitive DysfunctionImmunologyAgingTraumaMulti-organ DysfunctionRegenerative EffectsCognitive FunctionAnesthesiaAnalgesiaSurgical Procedure

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