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Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery

DOI:
10.3791/56760-v

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10:38 min

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January 15, 2018

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, , , ,
1Department of Chemical Engineering,Northeastern University, 2Nanomedicine Science and Technology Center,Northeastern University, 3Department of Physics,Northeastern University, 4Departments of Bioengineering,Northeastern University, 5Department of Neuroscience,Albert Einstein College of Medicine

Chapters

  • 00:05Title
  • 00:38Synthesis of Polyethylene Glycol-coated Gold Nanoparticles (PEG-AuNPs)
  • 03:13Conjugation of Fluorophores onto the PEG-AuNP NH2 Groups
  • 04:56Characterization of Fluorescent PEG-AuNPs
  • 08:46Results: Size and Biocompatibility of THPC-coated and Fluorescent PEG-AuNPs
  • 10:19Conclusion

Summary

Automatic Translation

Automatic Translation

We describe a method of synthesizing biocompatible 10-nm gold nanoparticles, functionalized by coating poly-ethylene glycol onto the surface. These particles can be used in vitro and in vivo for delivering therapeutics to nanoscale cellular and extracellular spaces that are difficult to access with conventional nanoparticle sizes.

Tags

Keywords: Gold NanoparticlesPolymer CoatingFunctionalizationEndothelium TargetingDrug DeliveryBiocompatibilityFluorescence ImagingTHPCChloroauric AcidPEGDialysisLyophilization

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