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Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm
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Behavior
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JoVE Journal Behavior
Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm

DOI:
10.3791/56983-v

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08:29 min

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June 07, 2018

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, , ,
1Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología,Universitat de València

Chapters

  • 00:05Title
  • 01:34Pre-conditioning
  • 03:06Conditioning and Post-conditioning
  • 04:22Extinction and Reinstatement of CPP
  • 06:11Results: Environmental Manipulations Modify Relapse in Cocaine Seeking in Mice
  • 07:35Conclusion

Summary

Automatic Translation

Automatic Translation

This protocol describes the Conditioned Place Preference (CPP) as a model of relapse. This procedure permits the measurement of relapse in laboratory animals, considering the impact of drug-associated environmental cues as craving and relapse in abstaining addicts is currently the focus of drug-abuse treatment programs.

Tags

Keywords: Drug-seekingReinstatementConditioned Place PreferenceCPPDrug AddictionRelapseEnvironmental CuesStressIncentive Motivational ValueEthologySocial DefeatHabituationCocaineMouse

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