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JoVE Journal
Bioengineering

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Overflade Functionalization af Hepatitis E Virus nanopartikler ved hjælp af kemiske konjugation metoder
 
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Overflade Functionalization af Hepatitis E Virus nanopartikler ved hjælp af kemiske konjugation metoder

Article DOI: 10.3791/57020
May 11th, 2018

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Summary May 11th, 2018

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Vi har manipuleret kapsid proteiner af hepatitis E virus som en theranostic nanopartikel (HEVNP). HEVNP samler selv i en stabil ikosaedriske bur i slimhinden levering. Her beskriver vi ændring af HEVNPs for tumor målretning af muterer overflade-eksponerede rester til cysteines, som konjugat syntetiske ligander, der specifikt binder tumorceller.

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