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Overflade Functionalization af Hepatitis E Virus nanopartikler ved hjælp af kemiske konjugation metoder
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
DOI:

09:12 min

May 11, 2018

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Chapters

  • 00:04Title
  • 00:50HEVNP Characterization
  • 02:46Chemical Conjugation of HEVNPs with Biotin, Cancer Targeting Ligand, and Fluorophores
  • 07:05Results: Production of LXY30-HEVNPs and Binding/Internalization of Fluorescently Labeled LXY30-HEVNPs in MDA-MB-231 Breast Cancer Cells
  • 08:35Conclusion

Summary

Automatic Translation

Vi har manipuleret kapsid proteiner af hepatitis E virus som en theranostic nanopartikel (HEVNP). HEVNP samler selv i en stabil ikosaedriske bur i slimhinden levering. Her beskriver vi ændring af HEVNPs for tumor målretning af muterer overflade-eksponerede rester til cysteines, som konjugat syntetiske ligander, der specifikt binder tumorceller.

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