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PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
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Medicine
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JoVE Journal Medicine
PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

DOI:
10.3791/57243-v

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12:01 min

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June 14, 2018

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, , ,
1Department of Radiology,Stanford University, 2Department of Neurology and Neurological Sciences,Stanford University

Chapters

  • 00:05Title
  • 02:20CT Acquisition
  • 03:34PET Acquistion
  • 05:48Dynamic PET Image Analysis
  • 10:23Results: [11C]DPA-713 is Effective in Quantifying Neuroinflammation in the dMCAO Mouse Model of Stroke
  • 11:00Conclusion

Summary

Automatic Translation

Automatic Translation

Positron Emission Tomography (PET) imaging of translocator protein 18 kDa (TSPO) provides a non-invasive means to visualize the dynamic role of neuroinflammation in the development and progression of brain diseases. This protocol describes TSPO-PET and ex vivo autoradiography to detect neuroinflammation in a mouse model of ischemic stroke.

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Keywords: PET ImagingNeuroinflammation[11C]DPA-713Mouse ModelIschemic StrokeTSPOAutoradiographyBrain DiseasesDynamic ImagingRadiotracer

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