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強化されたゲノム細胞や生物の多様な Cas9 リボ核蛋白質と編集

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

JoVE Journal
Genetics

This content is Free Access.

JoVE Journal Genetics

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

強化されたゲノム細胞や生物の多様な Cas9 リボ核蛋白質と編集

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33,493 Views

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09:51 min

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May 25, 2018

DOI:

10.3791/57350-v

DOI:

10.3791/57350-v

•

09:51 min

May 25, 2018

•

41 Views

Behnom Farboud*^1,2, Erin Jarvis*¹, Theodore L. Roth*^3,4,5,6, Jiyung Shin*^1,3, Jacob E. Corn^1,3, Alexander Marson^3,5,6,7,8,9, Barbara J. Meyer^1,2, Nipam H. Patel^1,10, Megan L. Hochstrasser³

¹Department of Molecular Cell Biology,University of California, Berkeley, ²Howard Hughes Medical Institute,University of California, Berkeley, ³Innovative Genomics Institute,University of California, Berkeley, ⁴Biomedical Sciences Graduate Program,University of California, San Francisco, ⁵Department of Microbiology and Immunology,University of California, San Francisco, ⁶Diabetes Center,University of California, San Francisco, ⁷Chan Zuckerberg Biohub, ⁸Department of Medicine,University of California, San Francisco, ⁹UCSF Helen Diller Family Comprehensive Cancer Center,University of California, San Francisco, ¹⁰Department of Integrative Biology,University of California, Berkeley

Transcript

Summary

組立 Cas9 を利用した複雑なリボ核タンパク質 (RNP) は正確で効率的なゲノムの編集のための強力な方法です。ひと初代細胞や両方の古典的なモデル有機体の出現など、ここでは、私たちは細胞や生物の広い範囲にわたってその有用性を強調します。

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