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A Closed-chest Model to Induce Transverse Aortic Constriction in Mice
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A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

DOI:
10.3791/57397-v

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08:10 min

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April 05, 2018

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, , , , , , ,
1Department of Anaesthesiology,University Hospital Bonn, 2Department of Cardiac Surgery,University Hospital Bonn, 3Institute of Physiology 2,University of Bonn, 4Department of Medicine – Cardiology,University Hospital Bonn

Chapters

  • 00:04Title
  • 01:01Induction of Anesthesia and Intubation
  • 02:57Preoperative Doppler Measurement and Thoracotomy
  • 04:03Banding the Transverse Aorta
  • 05:58Results: Induction of Successful Transverse Aortic Constriction in Mice
  • 07:30Conclusion

Summary

Automatic Translation

Automatic Translation

Here, we present a protocol of Transverse Aortic constriction (TAC) via a lateral thoracotomy. This technique is a minimally invasive, closed chest surgical procedure aiming to simulate pressure overload and heart failure in mice utilizing standard TAC laboratory settings.

Tags

Keywords: Transverse Aortic ConstrictionMurine Closed Chest ModelLeft Ventricular Myocardial HypertrophyMinimal Invasive TechniqueCardiac MacrophagiaRib CageSurgical TraumaAnesthesiaIntubationCarotid ArteriesDoppler Probe

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