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Developmental Biology

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JoVE Journal Developmental Biology
En familiær hyperkolesterolemi menneskelige leveren Chimeric musemodell med indusert Pluripotent Stamcelle-avledet hepatocytter
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En familiær hyperkolesterolemi menneskelige leveren Chimeric musemodell med indusert Pluripotent Stamcelle-avledet hepatocytter

Article DOI: 10.3791/57556-v • 10:56 min • September 15th, 2018
September 15th, 2018 •
*1,2,6, *2, *3, 1,2, 2, 2, 4,5, 4,5, 2, 4,5, 4,5, 4,5, 4,5, 3, 4,5,7, 1,2,6,7
1Department of Medicine, University of Hong Kong-Shenzhen Hospital, 2The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, 3School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, 4Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, 5Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 6Research Centre of Heart, Brain, Hormone, and Healthy Ageing, Li Ka Shing Faculty of Medicine, University of Hong Kong, 7Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre, University of Hong Kong and Guangzhou Institutes of Biomedicine and Health
* These authors contributed equally

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Her presenterer vi en protokoll for å generere en menneskelig leveren chimeric musemodell familiær hyperkolesterolemi med menneskelige indusert pluripotent Stamcelle-avledet hepatocytter. Dette er en verdifull modell for å teste nye behandlingsformer for hyperkolesterolemi.

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Utviklingspsykologi biologi problemet 139 Familial hyperkolesterolemi hepatocytter menneskelige leveren chimeric mus indusert pluripotent stamceller LDL-reseptor statiner PCSK9 antistoffer
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