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JoVE Journal Developmental Biology
Um modelo de Mouse quimérico fígado humano de hipercolesterolemia familiar usando hepatócitos de derivadas de células-tronco pluripotentes induzidas
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Um modelo de Mouse quimérico fígado humano de hipercolesterolemia familiar usando hepatócitos de derivadas de células-tronco pluripotentes induzidas

Article DOI: 10.3791/57556-v • 10:56 min • September 15th, 2018
September 15th, 2018 •
*1,2,6, *2, *3, 1,2, 2, 2, 4,5, 4,5, 2, 4,5, 4,5, 4,5, 4,5, 3, 4,5,7, 1,2,6,7
1Department of Medicine, University of Hong Kong-Shenzhen Hospital, 2The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, 3School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, 4Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, 5Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 6Research Centre of Heart, Brain, Hormone, and Healthy Ageing, Li Ka Shing Faculty of Medicine, University of Hong Kong, 7Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre, University of Hong Kong and Guangzhou Institutes of Biomedicine and Health
* These authors contributed equally

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Aqui, apresentamos um protocolo para gerar um modelo de rato quimérico fígado humano de hipercolesterolemia familiar, usando hepatócitos de células-tronco derivadas de humanas pluripotentes induzidas. Este é um modelo valioso para testar novas terapias para hipercolesterolemia.

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Biologia do desenvolvimento edição 139 hipercolesterolemia familiar hepatócitos ratos quiméricoes fígados humanos induzido pluripotentes células-tronco receptor de LDL as estatinas anticorpos PCSK9
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