In this article, we present a protocol to induce acute lung injury in pigs by central-venous injection of oleic acid. This is an established animal model for studying the acute respiratory distress syndrome (ARDS).
Kamuf, J., Garcia-Bardon, A., Ziebart, A., Thomas, R., Rümmler, R., Möllmann, C., Hartmann, E. K. Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome. J. Vis. Exp. (140), e57783, doi:10.3791/57783 (2018).