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Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology
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Bioengineering
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JoVE Journal Bioengineering
Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology

DOI:
10.3791/58003-v

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09:58 min

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July 21, 2018

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, , , , , ,
1John A. Paulson School of Engineering and Applied Sciences,Harvard University, 2Department of Chemistry and Chemical Biology,Harvard University, 3Department of Physics,Korea University

Chapters

  • 00:04Title
  • 00:41Fabrication of Mesh Electronics
  • 03:59Loading of Mesh Electronics into Needles
  • 04:32Stereotaxis Injection of Mesh Electronics into Live Mouse Brain
  • 06:16Input/output Interfacing
  • 08:06Neural Recording Experiments
  • 08:25Results: Representative Neural Recording Results
  • 09:17Conclusion

Summary

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Automatic Translation

Mesh electronics probes seamlessly integrate and provide stable, long-term, single-neuron level recording within the brain. This protocol uses mesh electronics for in vivo experiments, involving the fabrication of mesh electronics, loading into needles, stereotaxic injection, input/output interfacing, recording experiments, and histology of tissue containing mesh probes.

Tags

Keywords: Syringe-injectableMesh ElectronicsChronicRodentElectrophysiologyNeuroscienceAgingBrain DevelopmentBrain DiseasesGliosisSilicon WaferNickelSU-8PhotolithographyPhotoresistDeveloperIsopropyl AlcoholHot PlateLOR 3AS1805ChromiumGoldRemover PG

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