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Controllable Nucleation of Cavitation from Plasmonic Gold Nanoparticles for Enhancing High Intensity Focused Ultrasound Applications
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Engineering
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JoVE Journal Engineering
Controllable Nucleation of Cavitation from Plasmonic Gold Nanoparticles for Enhancing High Intensity Focused Ultrasound Applications

Controllable Nucleation of Cavitation from Plasmonic Gold Nanoparticles for Enhancing High Intensity Focused Ultrasound Applications

DOI:
10.3791/58045-v

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08:19 min

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October 05, 2018

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1School of Electronic and Electrical Engineering,University of Leeds, 2Leeds Institute of Cancer and Pathology,University of Leeds

Chapters

  • 00:04Title
  • 00:32Tissue Mimicking and Alignment Phantom Manufacture
  • 02:51Configuring Experimental Apparatus for Both Pulsed and Continuous Wave Studies
  • 05:46Cavitation Threshold Detection from Pulsed High-intensity Focused Ultrasound (HIFU)
  • 06:23Thermal Denaturation from Continuous Wave High-intensity Focused Ultrasound Exposures
  • 06:47Results: Cavitation Detection and Thermal Denaturation with High-intensity Focused Ultrasound Exposure
  • 07:44Conclusion

Summary

Automatic Translation

Automatic Translation

This protocol demonstrates the controllable nucleation of cavitation in gel phantoms, through simultaneous exposure to both near-infrared pulsed laser light and high intensity focused ultrasound (HIFU). The cavitation activity can then be used for enhancing imaging and/or therapeutic uses of HIFU.

Tags

Keywords: CavitationNucleationPlasmonic Gold NanoparticlesHigh Intensity Focused Ultrasound (HIFU)Laser UltrasoundPhantomAcrylamideBovine Serum AlbuminAlignment PhantomAcoustic AbsorberHydrophone

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