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JoVE Journal
Developmental Biology

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Nanoparticle-mediated siRNA Gene-silencing in Adult Zebrafish Heart
 

Nanoparticle-mediated siRNA Gene-silencing in Adult Zebrafish Heart

Article doi: 10.3791/58054
July 29th, 2018

Summary July 29th, 2018

It remains a major challenge to develop conditional gene-knockout or effective gene-knockdown in adult zebrafish organs. Here we report a protocol for performing nanoparticle-mediated siRNA gene-silencing in adult zebrafish heart, thus providing a new loss-of-function method for studying adult organs in zebrafish and other model organisms.

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