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Mouse Model of Pressure Ulcers After Spinal Cord Injury
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Bioengineering
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JoVE Journal Bioengineering
Mouse Model of Pressure Ulcers After Spinal Cord Injury

Mouse Model of Pressure Ulcers After Spinal Cord Injury

DOI:
10.3791/58188-v

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06:51 min

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March 09, 2019

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, , , , ,
1Department of Biomedical Engineering,Rutgers University, 2Center for Engineering in Medicine,Massachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children, 3Department of Surgery,Yale School of Medicine, Yale University

Chapters

  • 00:04Title
  • 00:35T9-T10 Spinal Laminectomy
  • 02:22T9-T10 Complete Spinal Injury
  • 03:11Induction of Skin Pressure Ulcer after Complete SCI
  • 04:22Post-operative Animal Care, Euthanasia, and Tissue Collection for Histology
  • 05:07Results: Skin Wound Histology and Impact on Healing
  • 06:15Conclusion

Summary

Automatic Translation

Automatic Translation

Here, we describe a simple method to induce clinically relevant skin pressure ulcers (PUs) in a mouse model of spinal cord injury (SCI). This model can be used in pre-clinical studies to screen for different therapeutics for healing PUs in SCI patients.

Tags

Keywords: Mouse ModelPressure UlcersSpinal Cord InjuryWound HealingLaminectomySCI SurgeryTransectionAnalgesiaBetadineDepilatory Cream

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