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Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
DOI:

09:04 min

September 10, 2018

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Chapters

  • 00:04Title
  • 01:11In Vivo Fluorescence Imaging
  • 02:35High-Frequency Ultrasound (HFUS) Embryonic Development Evaluation
  • 04:28High Pressure Liquid Chromatography (HPLC) Analysis
  • 06:18Results: Representative Placenta-Targeted Drug Delivery Analyses
  • 08:12Conclusion

Summary

Automatic Translation

We describe a system that utilizes three methods to evaluate the safety and effectiveness of placenta-targeted drug delivery: in vivo imaging to monitor nanoparticle accumulation, high-frequency ultrasound to monitor placental and fetal development, and HPLC to quantify drug delivery to tissue.

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