Synthesis of <sup>68</sup>Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T<sub>1</sub>)Magnetic Resonance Imaging

Irene Fern&#225;ndez-Barahona; Jes&#250;s Ruiz-Cabello; Fernando Herranz; Juan Pellico

doi:10.3791/58269

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Synthesis of ⁶⁸Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T₁)Magnetic Resonance Imaging

Synthesis of <sup>68</sup>Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T<sub>1</sub>)Magnetic Resonance Imaging

JoVE Journal
Biology

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JoVE Journal Biology

Synthesis of ⁶⁸Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T₁)Magnetic Resonance Imaging

6,471 Views

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07:26 min

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November 20, 2018

DOI:

10.3791/58269-v

DOI:

10.3791/58269-v

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07:26 min

November 20, 2018

•

6451 Views

Irene Fernández-Barahona¹, Jesús Ruiz-Cabello², Fernando Herranz¹, Juan Pellico³

¹Nanobiotechnology, Molecular Imaging and Metabolomics Lab,Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)²CIC biomaGUNE and CIBER de Enfermedades Respiratorias (CIBERES). Ikerbasque, Basque Foundation for Science,Universidad Complutense de Madrid (UCM)³Advanced Imaging Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC),CIBER de Enfermedades Respiratorias (CIBERES)

Summary

Here, we present a protocol to obtain⁶⁸Ga core-doped iron oxide nanoparticles via fast microwave-driven synthesis. The methodology renders PET/(T₁)MRI nanoparticles with radiolabeling efficiencies higher than 90% and radiochemical purity of 99% in a 20-min synthesis.