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Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging
 

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging

Article DOI: 10.3791/58269-v 07:26 min November 20th, 2018
November 20th, 2018

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Summary

Here, we present a protocol to obtain 68Ga core-doped iron oxide nanoparticles via fast microwave-driven synthesis. The methodology renders PET/(T1)MRI nanoparticles with radiolabeling efficiencies higher than 90% and radiochemical purity of 99% in a 20-min synthesis.

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Synthesis 68Ga Core-doped Iron Oxide Nanoparticles Dual PET/MR Imaging Microwave Technology Reproducible Iron Chloride Hexahydrate Citric Acid Trisodium Salt Dihydrate Water Microwave-adapted Flask Dynamic Protocol Temperature Time Pressure Power Hydrazine Hydrate Gel Filtration Desalting Column Distilled Water Final Mixture Flowthrough Plastic Tube Vial Gallium-68 Generator Hydrochloric Acid
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