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JoVE Journal
Chemistry

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Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production
 

Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production

Article doi: 10.3791/58428
October 26th, 2018

Summary October 26th, 2018

Positron-emission tomography (PET) imaging sites that are involved in multiple early clinical research trials need robust and versatile radiotracer manufacturing capabilities. Using the radiotracer [18F]Clofarabine as an example, we illustrate how to automate the synthesis of a radiotracer using a flexible, cassette-based radiosynthesizer and validate the synthesis for clinical use.

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