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Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
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JoVE Journal Chemistry
Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

DOI:
10.3791/58527-v

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08:09 min

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August 06, 2019

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, , , , , , ,
1Research Center of Clinical Oncology,Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, 2Department of General Surgery,The First Affiliated Hospital with Nanjing Medical University, 3School of Clinical Medicine,Xuzhou Medical University

Chapters

  • 00:04Title
  • 01:09Synthesis of BNHEMA Polymer (PBNHEMA)
  • 03:21Synthesis of BNHEMA-b-APMA polymer (BA)
  • 04:18Transfection Efficiency of mBG/ GFP-pDNA Polyplexes
  • 05:10Results: Analysis of the Targeted Plasma DNA Delivery
  • 07:11Conclusion

Summary

Automatic Translation

Automatic Translation

This work presents the preparation of methionine functionalized biocompatible block copolymers (mBG) via the reversible addition-fragmentation chain transfer (RAFT) method. The plasmid DNA complexing ability of the obtained mBG and their transfection efficiency were also investigated. The RAFT method is very beneficial for polymerizing monomers containing special functional groups.

Tags

MethionineBlock CopolymerRAFT PolymerizationBiocompatiblePlasmid DNA Delivery

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