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A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy
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A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy

Article DOI: 10.3791/58567-v • 09:32 min • January 30th, 2019
January 30th, 2019 •
1, 1, 1, 1, 2, 1
1Chemistry, University of Southampton, 2Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca

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Summary
Automatic Translation

A novel and straightforward variation of the shake-flask method was developed for accurate lipophilicity measurement of fluorinated compounds by 19F NMR spectroscopy.

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Lipophilicity LogP Measurement 19F NMR Spectroscopy Lipophilicity Measurement Fluorine NMR Organic Compounds Medicinal Chemistry Reference Compound Sampling NMR Tube Sealing NMR Software Compound X HPLC-grade N-Octanol HPLC-grade Water Temperature Controlled Receptacle Stir Plate Recirculating Chiller
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