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Engineering

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Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles
 

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Article doi: 10.3791/58640
November 17th, 2018

Summary November 17th, 2018

Antigen-specific T cells are difficult to characterize or utilize in therapies due to their extremely low frequency. Herein, we provide a protocol to develop a magnetic particle which can bind to antigen-specific T cells to enrich these cells and then to expand them several hundred-fold for both characterization and therapy.

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