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JoVE Journal
Immunology and Infection

This content is Open Access.

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
 

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Article doi: 10.3791/58946
January 22nd, 2019

Summary January 22nd, 2019

This paper uses a flow-cytometry-based assay to screen libraries of chemical inhibitors for the identification of inhibitors and their targets that influence T-cell receptor signaling. The methods described here can also be expanded for high-throughput screenings.

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