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JoVE Journal
Bioengineering

This content is Open Access.

Ultra-long Read Sequencing for Whole Genomic DNA Analysis
 

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Article DOI: 10.3791/58954
March 15th, 2019

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Summary March 15th, 2019

Long-read sequences greatly facilitate the assembly of complex genomes and characterization of structural variation. We describe a method to generate ultra-long sequences by nanopore-based sequencing platforms. The approach adopts an optimized DNA extraction followed by modified library preparations to generate hundreds of kilobase reads with moderate coverage from human cells.

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