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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Yeast As a Chassis for Developing Functional Assays to Study Human P53
JoVE Journal
Cancer Research
Author Produced
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JoVE Journal Cancer Research
Yeast As a Chassis for Developing Functional Assays to Study Human P53

Yeast As a Chassis for Developing Functional Assays to Study Human P53

9,519 Views

14:57 min

August 04, 2019

DOI:

14:57 min
August 04, 2019

9495 Views
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Summary

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Presented here are four protocols to construct and exploit yeast Saccharomyces cerevisiae reporter strains to study human P53 transactivation potential, impacts of its various cancer-associated mutations, co-expressed interacting proteins, and the effects of specific small molecules.

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