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JoVE Journal
Immunology and Infection

This content is Open Access.

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
 

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Article doi: 10.3791/59126
February 28th, 2019

Summary February 28th, 2019

This protocol describes the use of single chain MHC class I complexes to investigate molecular interactions in human CD8+ T cell activation: generation of engineered antigen presenting cells expressing single chain constructs, culture of human CD8+ T cell clone and T cell activation experiments.

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