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Journal / Immunology and Infection / Induktion af lægemiddelinduceret, autoimmun…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Induktion af lægemiddelinduceret, autoimmun hepatitis i BALB / c-mus til undersøgelse af dets patogene mekanismer
Leukocyte Infiltration of Cremaster Muscle in Mice Assessed by Intravital Microscopy
Journal (Immunology and Infection)
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Native Polyacrylamide Gel Electrophoresis Immunoblot Analysis of Endogenous IRF5 Dimerization
Journal (Immunology and Infection)
Native Polyacrylamide Gel Electrophoresis Immunoblot Analysis of Endogenous IRF5 Dimerization
 
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Induktion af lægemiddelinduceret, autoimmun hepatitis i BALB / c-mus til undersøgelse af dets patogene mekanismer

Article DOI: 10.3791/59174-v • 11:36 min • May 29th, 2020
May 29th, 2020 •
1, 1, 1, 1, 1,2
1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 2Department of Pediatrics and Pathology, Johns Hopkins University

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Vi beskriver en in vivo immunisering, translationel hepatitis model i BALB / c mus, der kan bruges til at studere patogenesen af lægemiddelinduceret autoimmun hepatitis, herunder kønsforskelle set i denne sygdom. Vi vil beskrive, hvordan denne model demonstrerer reproducerbare analyser ved hjælp af in vivo og in vitro eksperimentelle teknikker.

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Immunologi og infektion udgave 159 hepatitis lægemiddelinduceret immunmedieret autoimmunitet cytokrom P450 2E autoantistof mitokondrier oxidativ stress Foxp3 +Tregs sex
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