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Mimicking a Space Mission to Mars Using Hindlimb Unloading and Partial Weight Bearing in Rats
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JoVE Journal Behavior
Mimicking a Space Mission to Mars Using Hindlimb Unloading and Partial Weight Bearing in Rats

Mimicking a Space Mission to Mars Using Hindlimb Unloading and Partial Weight Bearing in Rats

DOI:
10.3791/59327-v

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05:54 min

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April 04, 2019

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, , ,
1Department of Neurology,Harvard Medical School – Beth Israel Deaconess Medical Center, 2Department of Orthopaedics,Harvard Medical School – Beth Israel Deaconess Medical Center

Chapters

  • 00:04Title
  • 01:01Hindlimb Unloading
  • 02:06Partial Weight Bearing
  • 03:09Assessment of Hindlimb Grip Force
  • 03:46Results: Mimic a Space Mission to Mars Using Hindlimb Unloading and Partial Weight Bearing in Rats
  • 04:59Conclusion

Summary

Automatic Translation

Automatic Translation

By using an innovative ground-based analogue model, we are able to simulate a space mission including a trip to (0 g) and a stay on Mars (0.38 g) in rats. This model allows for a longitudinal assessment of the physiological changes occurring during the two hypo-gravitational stages of the mission.

Tags

Keywords: Hindlimb UnloadingPartial Weight BearingRat ModelMars MissionPhysiological ChangesBehaviorMemoryPerformanceStressGround-based ModelSpace ExplorationAnesthesiaSuspension Device

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