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JoVE Journal
Medicine

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Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research
 

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

Article DOI: 10.3791/59458-v 09:36 min April 26th, 2019
April 26th, 2019

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Summary

Vascularized composite allograft offers life-altering benefits to transplant recipients, but the biological causes of graft rejection and vasculopathy remain poorly understood. The rodent surgical model presented here offers a reproducible, clinically relevant model of transplantation, allowing researchers to evaluate rejection events and potential therapeutic strategies to prevent their occurrence.

Tags

Vascularized Composite Allotransplantation Animal Model Graft Rejection Skin Muscle Bone Orthotopic Models Vasculopathy Ischemic Damage Surgical Model Macrovascular Surgical Techniques Hind Limb Harvest Donor Rat Femoral Vessels Disarticulation Pedicle Transection Recipient Surgical Table
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