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Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research
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Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

DOI:
10.3791/59458-v

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09:36 min

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April 26, 2019

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, , , , , ,
1Christine M. Kleinert Institute for Hand and Microsurgery, 2Cardiovascular Innovation Institute,University of Louisville, 3Kentucky Spinal Cord Injury Research Center,University of Louisville, 4Department of Physiology,University of Louisville

Chapters

  • 00:04Title
  • 01:05Procedure Overview
  • 02:03Donor Allograft Harvest
  • 05:16Recipient Transplantation Surgery
  • 07:26Results: Histopathological Follow-up and Analysis After Vascularized Composite Allotransplantation (VCA)
  • 09:05Conclusion

Summary

Automatic Translation

Automatic Translation

Vascularized composite allograft offers life-altering benefits to transplant recipients, but the biological causes of graft rejection and vasculopathy remain poorly understood. The rodent surgical model presented here offers a reproducible, clinically relevant model of transplantation, allowing researchers to evaluate rejection events and potential therapeutic strategies to prevent their occurrence.

Tags

Keywords: Vascularized Composite AllotransplantationHindlimb Osteomyocutaneous FlapRat ModelVasculopathyGraft RejectionMacrovascular Surgical TechniquesIschemic DamageSkinMuscleBoneOrthotopic ModelsHand TransplantDonor VesselsRecipient Surgical SiteInguinal Pocket

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